| Gene Information | |
|---|---|
| Gene Name | PML |
| Organism | Homo sapiens (Human) |
| Gene Length | 882 |
| Protein Names | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) |
| Target Name | protein pml |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000140464 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P29590 |
| Gene Card | PML |
| Uniprot ID | P29590 |
| Pfam | PF12126; PF00643 |
| In ASD | no |
| Allosteric Prediction | yes (1.000418381) |
| Ortholog in Animals | Alpaca_ PML ( ortholog_one2one ) Dog_ PML ( ortholog_one2one ) GuineaPig_ PML ( ortholog_one2one ) Macaque_ PML ( ortholog_one2one ) Mouse_ Pml ( ortholog_one2one ) Pig_ PML ( ortholog_one2one ) Rat_ Pml ( ortholog_one2one ) Rabbit_ PML ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.004925(Chimpanzee);0.009983(Mouse);NULL(Rat);0.024615(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BOR (NMR - ) 2MVW (NMR - ) 2MWX (NMR - ) 4WJN (X-ray 1.50A ) 4WJO (X-ray 1.46A ) 5YUF (X-ray 1.60A ) 6IMQ (X-ray 2.06A ) 6UYO (X-ray 1.64A ) 6UYP (X-ray 1.42A ) 6UYQ (X-ray 1.50A ) 6UYR (X-ray 1.30A ) 6UYS (X-ray 1.59A ) 6UYT (X-ray 1.66A ) 6UYU (X-ray 1.66A ) 6UYV (X-ray 1.40A ) 8DJI (X-ray 1.97A ) |
| DBSNP | rs5742915 |
| Subcellular location [CC] | Nucleus. Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:27211601}. Nucleus, PML body {ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:27211601}. Nucleus, nucleolus. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein. |
| Mouse PG classification | NA |
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