| Gene Information | |
|---|---|
| Gene Name | PRSS22 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Brain-specific serine protease 4 (BSSP-4) (EC 3.4.21.-) (Serine protease 22) (Serine protease 26) (Tryptase epsilon) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000005001 ) 3 ( ENSG00000282937 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9GZN4 |
| Gene Card | PRSS22 |
| Uniprot ID | Q9GZN4 |
| Pfam | PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-1.503500713) |
| Ortholog in Animals | Alpaca_ PRSS22 ( ortholog_one2one ) GuineaPig_ PRSS22 ( ortholog_one2one ) Macaque_ PRSS22 ( ortholog_one2one ) Mouse_ Prss22 ( ortholog_one2one ) Pig_ PRSS22 ( ortholog_one2one ) Rat_ Prss22 ( ortholog_one2one ) |
| Ohnologs | PRSS8, TMPRSS6, TMPRSS11B |
| Paralogs | TMPRSS15, TMPRSS6, HPN, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | tongue, esophagus.mucosa, minor.salivary.gland |
| Tissue Specificity | Expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung. Scarce in adult lung. Expressed at low levels in placenta, pancreas, prostate and thyroid gland. {ECO:0000269|PubMed:11602603}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11602603}. |
| Mouse PG classification | NA |
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