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Gene Information
Gene Name
F7
Organism
Homo sapiens (Human)
Gene Length
466
Protein Names
Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
Target Name
coagulation factor vii
Target Type
NA
Gene Age
950 ( ENSG00000057593 )
Evolutionary Stage
Eukaryota
AlphaFoldDB
P08709
Gene Card
F7
Uniprot ID
P08709
Pfam
PF00008; PF00594; PF00089
In ASD
yes
Allosteric Prediction
yes (1.221290186)
Ortholog in Animals
Alpaca_ F7 ( ortholog_one2many )
Dog_ F7 ( ortholog_one2one )
GuineaPig_ F7 ( ortholog_one2one )
Macaque_ F7 ( ortholog_one2one )
Mouse_ F7 ( ortholog_one2one )
Pig_ F7 ( ortholog_one2one )
Rat_ F7 ( ortholog_one2one )
Ohnologs
PROC
Paralogs
HGFAC, C1R, KLK10, F9, F12, F10, CFI, CFD, PRSS55, PRSS51, C1S, C1RL, HP, HPR, KLKB1, F11
Tissue
liver
Tissue Specificity
Plasma.
Pharmacological Animal Models
NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1BF9
(NMR
-
)
1CVW
(X-ray
2.28A
)
1DAN
(X-ray
2.00A
)
1DVA
(X-ray
3.00A
)
1F7E
(NMR
-
)
1F7M
(NMR
-
)
1FAK
(X-ray
2.10A
)
1FF7
(NMR
-
)
1FFM
(NMR
-
)
1J9C
(X-ray
2.90A
)
1JBU
(X-ray
2.00A
)
1KLI
(X-ray
1.69A
)
1KLJ
(X-ray
2.44A
)
1O5D
(X-ray
2.05A
)
1QFK
(X-ray
2.80A
)
1W0Y
(X-ray
2.50A
)
1W2K
(X-ray
3.00A
)
1W7X
(X-ray
1.80A
)
1W8B
(X-ray
3.00A
)
1WQV
(X-ray
2.50A
)
1WSS
(X-ray
2.60A
)
1WTG
(X-ray
2.20A
)
1WUN
(X-ray
2.40A
)
1WV7
(X-ray
2.70A
)
1YGC
(X-ray
2.00A
)
1Z6J
(X-ray
2.00A
)
2A2Q
(X-ray
1.80A
)
2AEI
(X-ray
2.52A
)
2AER
(X-ray
1.87A
)
2B7D
(X-ray
2.24A
)
2B8O
(X-ray
2.80A
)
2BZ6
(X-ray
1.60A
)
2C4F
(X-ray
1.72A
)
2EC9
(X-ray
2.00A
)
2F9B
(X-ray
2.54A
)
2FIR
(X-ray
2.00A
)
2FLB
(X-ray
1.95A
)
2FLR
(X-ray
2.35A
)
2PUQ
(X-ray
2.05A
)
2ZP0
(X-ray
2.70A
)
2ZWL
(X-ray
2.20A
)
2ZZU
(X-ray
2.50A
)
3ELA
(X-ray
2.20A
)
3TH2
(X-ray
1.72A
)
3TH3
(X-ray
2.70A
)
3TH4
(X-ray
1.80A
)
4IBL
(X-ray
1.80A
)
4ISH
(X-ray
1.82A
)
4ISI
(X-ray
1.94A
)
4JYU
(X-ray
1.80A
)
4JYV
(X-ray
2.19A
)
4JZD
(X-ray
2.20A
)
4JZE
(X-ray
1.52A
)
4JZF
(X-ray
1.84A
)
4NA9
(X-ray
2.24A
)
4NG9
(X-ray
2.20A
)
4NGA
(X-ray
2.15A
)
4X8S
(X-ray
2.10A
)
4X8T
(X-ray
2.20A
)
4X8U
(X-ray
2.10A
)
4X8V
(X-ray
2.50A
)
4YLQ
(X-ray
1.40A
)
4YT6
(X-ray
2.07A
)
4YT7
(X-ray
2.30A
)
4Z6A
(X-ray
2.25A
)
4ZMA
(X-ray
2.30A
)
4ZXX
(X-ray
2.60A
)
4ZXY
(X-ray
2.06A
)
5I46
(X-ray
2.06A
)
5L0S
(X-ray
1.45A
)
5L2Y
(X-ray
1.82A
)
5L2Z
(X-ray
1.79A
)
5L30
(X-ray
1.73A
)
5PA8
(X-ray
1.98A
)
5PA9
(X-ray
1.55A
)
5PAA
(X-ray
1.98A
)
5PAB
(X-ray
1.99A
)
5PAC
(X-ray
1.50A
)
5PAE
(X-ray
1.45A
)
5PAF
(X-ray
1.50A
)
5PAG
(X-ray
1.36A
)
5PAI
(X-ray
1.73A
)
5PAJ
(X-ray
1.70A
)
5PAK
(X-ray
1.56A
)
5PAM
(X-ray
1.60A
)
5PAN
(X-ray
1.62A
)
5PAO
(X-ray
1.40A
)
5PAQ
(X-ray
1.59A
)
5PAR
(X-ray
2.10A
)
5PAS
(X-ray
1.48A
)
5PAT
(X-ray
1.60A
)
5PAU
(X-ray
1.55A
)
5PAV
(X-ray
1.40A
)
5PAW
(X-ray
2.20A
)
5PAX
(X-ray
1.36A
)
5PAY
(X-ray
1.66A
)
5PB0
(X-ray
1.98A
)
5PB1
(X-ray
1.90A
)
5PB2
(X-ray
1.45A
)
5PB3
(X-ray
1.90A
)
5PB4
(X-ray
2.43A
)
5PB5
(X-ray
1.84A
)
5PB6
(X-ray
1.90A
)
5TQE
(X-ray
1.90A
)
5TQF
(X-ray
1.85A
)
5TQG
(X-ray
1.90A
)
5U6J
(X-ray
2.30A
)
DBSNP
rs387906507
rs45572939
rs1448296564
rs745374448
rs121964935
rs776354144
rs121964932
rs150525536
rs776796178
rs146795869
rs563972504
rs763458490
rs771335282
rs200016360
rs143855920
rs1258691292
rs764971156
rs1479693459
rs1234759020
rs372577568
rs1250204261
rs762621913
rs868044209
rs1438503836
rs121964928
rs1160146175
rs1269916662
rs753266903
rs764807079
rs751028917
rs550074221
rs779589651
rs6045
rs770328850
rs773627551
rs121964931
rs147680958
rs121964929
rs201991361
rs778138366
rs749760143
rs146698837
rs200212201
rs139372641
rs1250853566
rs747876824
rs3093267
rs36209567
rs149283257
rs928183869
rs963430078
rs121964926
rs750980786
rs747673406
rs121964927
rs137919286
rs531225271
rs1595080725
rs1215224419
rs121964938
rs121964934
rs190485816
rs748979195
rs121964936
rs1566910847
rs6046
rs121964937
rs121964930
rs755377592
rs1450120320
rs756956471
rs758213652
rs3093248
Subcellular location [CC]
Secreted.
Mouse PG classification
NA
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