| Gene Information | |
|---|---|
| Gene Name | CYSLTR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 337 |
| Protein Names | Cysteinyl leukotriene receptor 1 (CysLTR1) (Cysteinyl leukotriene D4 receptor) (LTD4 receptor) (G-protein coupled receptor HG55) (HMTMF81) |
| Target Name | cysteinyl leukotriene receptor 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000173198 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y271 |
| Gene Card | CYSLTR1 |
| Uniprot ID | Q9Y271 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999920081) |
| Ortholog in Animals | Alpaca_ CYSLTR1 ( ortholog_one2one ) Dog_ CYSLTR1 ( ortholog_one2one ) GuineaPig_ CYSLTR1 ( ortholog_one2one ) Macaque_ CYSLTR1 ( ortholog_one2one ) Mouse_ Cysltr1 ( ortholog_one2one ) Pig_ CYSLTR1 ( ortholog_one2one ) Rat_ Cysltr1 ( ortholog_one2one ) Rabbit_ CYSLTR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR20, LPAR4, LPAR6, P2RY10, GPR35, GPR55, F2RL2, P2RY8, F2RL1, F2R, F2RL3, CYSLTR2, GPR18, GPR17, GPR65, GPR4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6RZ4 (X-ray 2.70A ) 6RZ5 (X-ray 2.53A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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