Gene Information
Gene NameCASK
OrganismHomo sapiens (Human)
Gene Length926
Protein NamesPeripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Target Nameperipheral plasma membrane protein cask
Target TypeNA
Gene Age680 ( ENSG00000147044 )
Evolutionary StageEukaryota
AlphaFoldDBO14936
Gene CardCASK
Uniprot IDO14936
PfamPF00625; PF02828; PF00595; PF00069; PF00018
In ASDno
Allosteric Predictionyes (0.901900403)
Ortholog in AnimalsAlpaca_ CASK ( ortholog_one2one )
Dog_ CASK ( ortholog_one2one )
GuineaPig_ CASK ( ortholog_one2one )
Macaque_ CASK ( ortholog_one2many )
Mouse_ Cask ( ortholog_one2one )
Pig_ CASK ( ortholog_one2one )
Rat_ Cask ( ortholog_one2one )
Rabbit_ CASK ( ortholog_one2one )
OhnologsNA
ParalogsMPP3, MPP7, MPP2, PALS1, PALS2, MPP1, MPP4
TissueNA
Tissue SpecificityUbiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. {ECO:0000269|PubMed:11003712}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1KGD  (X-ray  1.31A  )  1KWA  (X-ray  1.93A  )  1ZL8  (NMR  -  )  3C0G  (X-ray  2.19A  )  3C0H  (X-ray  2.30A  )  3C0I  (X-ray  1.85A  )  3MFR  (X-ray  2.00A  )  3MFS  (X-ray  2.10A  )  3MFT  (X-ray  2.20A  )  3MFU  (X-ray  2.30A  )  3TAC  (X-ray  2.20A  )  6KMH  (X-ray  2.40A  )  7OAI  (X-ray  2.30A  )  7OAJ  (X-ray  1.93A  )  7OAK  (X-ray  2.23A  )  7OAL  (X-ray  2.17A  ) 
DBSNP rs137852816  rs137852817  rs137852820  rs137852818 
Subcellular location [CC]Nucleus {ECO:0000250|UniProtKB:Q62915}. Cytoplasm {ECO:0000250|UniProtKB:Q62915}. Cell membrane {ECO:0000250|UniProtKB:Q62915};
Peripheral membrane protein {ECO:0000250|UniProtKB:Q62915}.
Mouse PG classificationHPG
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