| Gene Information | |
|---|---|
| Gene Name | PTPRJ |
| Organism | Homo sapiens (Human) |
| Gene Length | 1337 |
| Protein Names | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149177 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12913 |
| Gene Card | PTPRJ |
| Uniprot ID | Q12913 |
| Pfam | PF00041; PF18861; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.892187349) |
| Ortholog in Animals | Alpaca_ PTPRJ ( ortholog_one2one ) Dog_ PTPRJ ( ortholog_one2one ) GuineaPig_ PTPRJ ( ortholog_one2one ) Macaque_ PTPRJ ( ortholog_one2one ) Mouse_ Ptprj ( ortholog_one2one ) Pig_ PTPRJ ( ortholog_one2one ) Rat_ Ptprj ( ortholog_one2one ) Rabbit_ PTPRJ ( ortholog_one2one ) |
| Ohnologs | PTPRB |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density. {ECO:0000269|PubMed:12370829, ECO:0000269|PubMed:8483328, ECO:0000269|PubMed:9531590}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CFV (X-ray 2.50A ) 2DLE (NMR - ) 2NZ6 (X-ray 2.30A ) |
| DBSNP | rs121434507 rs1566734 rs2229701 rs1503185 rs2229703 rs4752904 rs11039554 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane {ECO:0000250}. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. |
| Mouse PG classification | NA |
| click here to return to the previous page | |