| Gene Information | |
|---|---|
| Gene Name | PUM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1186 |
| Protein Names | Pumilio homolog 1 (HsPUM) (Pumilio-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000134644 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14671 |
| Gene Card | PUM1 |
| Uniprot ID | Q14671 |
| Pfam | PF00806 |
| In ASD | no |
| Allosteric Prediction | no (-0.907283536) |
| Ortholog in Animals | Alpaca_ PUM1 ( ortholog_one2one ) Dog_ PUM1 ( ortholog_one2one ) GuineaPig_ PUM1 ( ortholog_one2one ) Macaque_ PUM1 ( ortholog_one2one ) Mouse_ Pum1 ( ortholog_one2one ) Pig_ PUM1 ( ortholog_one2one ) Rat_ Pum1 ( ortholog_one2one ) Rabbit_ PUM1 ( ortholog_one2one ) |
| Ohnologs | PUM2 |
| Paralogs | PUM2 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:12459267}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002043(Rat);0.019048(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IB2 (X-ray 1.90A ) 1M8W (X-ray 2.20A ) 1M8X (X-ray 2.20A ) 1M8Y (X-ray 2.60A ) 1M8Z (X-ray 1.90A ) 2YJY (X-ray 2.60A ) 3BSB (X-ray 2.80A ) 3BSX (X-ray 2.32A ) 3Q0L (X-ray 2.50A ) 3Q0M (X-ray 2.70A ) 3Q0N (X-ray 2.40A ) 3Q0O (X-ray 2.80A ) 3Q0P (X-ray 2.60A ) 5YKH (X-ray 2.46A ) 5YKI (X-ray 2.25A ) |
| DBSNP | rs771145682 rs1557541619 rs1557539450 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305|PubMed:26724866}. Cytoplasm, P-body {ECO:0000305|PubMed:20818387}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Note=Recruited to cytoplasmic stress granules upon viral infection. {ECO:0000269|PubMed:25340845}. |
| Mouse PG classification | NA |
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