| Gene Information | |
|---|---|
| Gene Name | PTPRT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1441 |
| Protein Names | Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000196090 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14522 |
| Gene Card | PTPRT |
| Uniprot ID | O14522 |
| Pfam | PF00041; PF00629; PF00102 |
| In ASD | no |
| Allosteric Prediction | no (-0.436359822) |
| Ortholog in Animals | Alpaca_ PTPRT ( ortholog_one2one ) Dog_ PTPRT ( ortholog_one2one ) GuineaPig_ PTPRT ( ortholog_one2one ) Macaque_ PTPRT ( ortholog_one2one ) Mouse_ Ptprt ( ortholog_one2one ) Pig_ PTPRT ( ortholog_one2one ) Rat_ Ptprt ( ortholog_one2one ) Rabbit_ PTPRT ( ortholog_one2one ) |
| Ohnologs | PTPRU, PTPRK, PTPRM |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | brain, cerebral.cortex, oviduct |
| Tissue Specificity | Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes. {ECO:0000269|PubMed:15155950}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OOQ (X-ray 1.80A ) |
| DBSNP | rs2867655 rs17811401 rs1371429276 rs749647294 rs1217327426 rs370873414 rs761148007 rs1568910321 rs199947379 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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