| Gene Information | |
|---|---|
| Gene Name | PTPRS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1948 |
| Protein Names | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) |
| Target Name | protein-tyrosine phosphatase sigma |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000105426 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13332 |
| Gene Card | PTPRS |
| Uniprot ID | Q13332 |
| Pfam | PF00041; PF07679; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.427067639) |
| Ortholog in Animals | Alpaca_ PTPRS ( ortholog_one2many ) Dog_ PTPRS ( ortholog_one2one ) GuineaPig_ PTPRS ( ortholog_one2one ) Macaque_ PTPRS ( ortholog_one2one ) Mouse_ Ptprs ( ortholog_one2one ) Pig_ PTPRS ( ortholog_one2one ) Rat_ Ptprs ( ortholog_one2one ) |
| Ohnologs | PTPRF, PTPRD |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21, PTPRD |
| Tissue | NA |
| Tissue Specificity | Detected in peripheral blood plasmacytoid dendritic cells (at protein level) (PubMed:26231120). Detected in all tissues tested except for placenta and liver (PubMed:8524829, PubMed:8992885). Detected in peripheral blood plasmacytoid dendritic cells (PubMed:26231120). {ECO:0000269|PubMed:26231120, ECO:0000269|PubMed:8524829, ECO:0000269|PubMed:8992885}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2FH7 (X-ray 2.00A ) 2YD2 (X-ray 2.55A ) 2YD3 (X-ray 2.30A ) 2YD9 (X-ray 2.60A ) 4BPC (X-ray 2.10A ) 4PBX (X-ray 3.15A ) |
| DBSNP | rs775778266 rs4807697 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26231120}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:B0V2N1}. Perikaryon {ECO:0000250|UniProtKB:B0V2N1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q64605}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q64605}. Postsynaptic density {ECO:0000250|UniProtKB:Q64605}. Cell projection, neuron projection {ECO:0000250|UniProtKB:B0V2N1}. Cell projection, growth cone {ECO:0000250|UniProtKB:B0V2N1}. Note=Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (By similarity). {ECO:0000250|UniProtKB:B0V2N1, ECO:0000269|PubMed:26231120}. |
| Mouse PG classification | NA |
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