| Gene Information | |
|---|---|
| Gene Name | PTPRR |
| Organism | Homo sapiens (Human) |
| Gene Length | 657 |
| Protein Names | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000153233 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q15256 |
| Gene Card | PTPRR |
| Uniprot ID | Q15256 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.038626213) |
| Ortholog in Animals | Alpaca_ PTPRR ( ortholog_one2one ) Dog_ PTPRR ( ortholog_one2one ) GuineaPig_ PTPRR ( ortholog_one2one ) Macaque_ PTPRR ( ortholog_one2one ) Mouse_ Ptprr ( ortholog_one2one ) Pig_ PTPRR ( ortholog_one2one ) Rat_ Ptprr ( ortholog_one2one ) Rabbit_ PTPRR ( ortholog_one2one ) |
| Ohnologs | PTPN5, PTPN7 |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. {ECO:0000269|PubMed:10705342}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.070650(Mouse);0.002990(Rat);0.080000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2A8B (X-ray 2.30A ) |
| DBSNP | rs35987017 rs3803036 rs35387004 rs35390084 |
| Subcellular location [CC] | [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. |
| Mouse PG classification | NA |
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