Gene Information
Gene NamePTPRB
OrganismHomo sapiens (Human)
Gene Length1997
Protein NamesReceptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)
Target Nameprotein tyrosine phosphatase beta
Target TypeClinical trial target
Gene Age1292 ( ENSG00000127329 )
Evolutionary StageEukaryota
AlphaFoldDBP23467
Gene CardPTPRB
Uniprot IDP23467
PfamPF00041; PF18861; PF00102
In ASDno
Allosteric Predictionyes (1.002392782)
Ortholog in AnimalsAlpaca_ PTPRB ( ortholog_one2one )
Dog_ PTPRB ( ortholog_one2one )
GuineaPig_ PTPRB ( ortholog_one2one )
Macaque_ PTPRB ( ortholog_one2one )
Mouse_ Ptprb ( ortholog_one2one )
Pig_ PTPRB ( ortholog_one2one )
Rat_ Ptprb ( ortholog_one2one )
Rabbit_ PTPRB ( ortholog_one2one )
OhnologsPTPRH, PTPRJ
ParalogsPTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2AHS  (X-ray  2.10A  )  2H02  (X-ray  2.30A  )  2H03  (X-ray  1.65A  )  2H04  (X-ray  2.30A  )  2HC1  (X-ray  1.30A  )  2HC2  (X-ray  1.40A  )  2I3R  (X-ray  1.85A  )  2I3U  (X-ray  1.85A  )  2I4E  (X-ray  1.75A  )  2I4G  (X-ray  1.65A  )  2I4H  (X-ray  2.15A  )  2I5X  (X-ray  1.70A  ) 
DBSNP rs2252784  rs2465811  rs36027530  rs2165627  rs2304821  rs34902691  rs17226367 
Subcellular location [CC]Membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}.
Mouse PG classificationNA
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