| Gene Information | |
|---|---|
| Gene Name | PTPRA |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132670 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P18433 |
| Gene Card | PTPRA |
| Uniprot ID | P18433 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.555439471) |
| Ortholog in Animals | Alpaca_ PTPRA ( ortholog_one2one ) Dog_ PTPRA ( ortholog_one2one ) GuineaPig_ PTPRA ( ortholog_one2one ) Macaque_ PTPRA ( ortholog_one2one ) Mouse_ Ptpra ( ortholog_one2one ) Pig_ PTPRA ( ortholog_one2one ) Rat_ Ptpra ( ortholog_one2one ) Rabbit_ PTPRA ( ortholog_one2one ) |
| Ohnologs | PTPRE |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6UZT (X-ray 1.80A ) |
| DBSNP | rs1178027 |
| Subcellular location [CC] | Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18052}. Note=Localizes to focal adhesion sites following integrin engagement. {ECO:0000250|UniProtKB:P18052}. |
| Mouse PG classification | NA |
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