| Gene Information | |
|---|---|
| Gene Name | PTPN5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 565 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000110786 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P54829 |
| Gene Card | PTPN5 |
| Uniprot ID | P54829 |
| Pfam | PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999571759) |
| Ortholog in Animals | Alpaca_ PTPN5 ( ortholog_one2one ) Dog_ PTPN5 ( ortholog_one2one ) GuineaPig_ PTPN5 ( ortholog_one2one ) Macaque_ PTPN5 ( ortholog_one2one ) Mouse_ Ptpn5 ( ortholog_one2one ) Pig_ PTPN5 ( ortholog_one2one ) Rat_ Ptpn5 ( ortholog_one2one ) Rabbit_ PTPN5 ( ortholog_one2one ) |
| Ohnologs | PTPRR, PTPN7 |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | brain, cerebral.cortex, caudate.nucleus, putamen, nucleus.accumbens |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BIJ (X-ray 2.05A ) 2BV5 (X-ray 1.80A ) 2CJZ (X-ray 1.70A ) 5OVR (X-ray 2.15A ) 5OVX (X-ray 2.10A ) 5OW1 (X-ray 2.05A ) 6H8R (X-ray 1.66A ) |
| DBSNP | rs4757707 rs11024773 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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