| Gene Information | |
|---|---|
| Gene Name | PTPN3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 913 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000070159 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P26045 |
| Gene Card | PTPN3 |
| Uniprot ID | P26045 |
| Pfam | PF09380; PF00373; PF09379; PF00595; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.928635226) |
| Ortholog in Animals | Alpaca_ PTPN3 ( ortholog_one2one ) Dog_ PTPN3 ( ortholog_one2one ) GuineaPig_ PTPN3 ( ortholog_one2one ) Macaque_ PTPN3 ( ortholog_one2one ) Mouse_ Ptpn3 ( ortholog_one2one ) Pig_ PTPN3 ( ortholog_one2one ) Rat_ Ptpn3 ( ortholog_one2one ) Rabbit_ PTPN3 ( ortholog_one2one ) |
| Ohnologs | PTPN4 |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2B49 (X-ray 1.54A ) 4QUM (X-ray 2.52A ) 4QUN (X-ray 1.86A ) 4RH5 (X-ray 1.60A ) 4RH9 (X-ray 1.60A ) 4RHG (X-ray 1.58A ) 4RI4 (X-ray 1.60A ) 4RI5 (X-ray 1.26A ) 4S0G (X-ray 1.72A ) 6HKS (X-ray 2.19A ) 6T36 (X-ray 1.86A ) |
| DBSNP | rs35285139 rs3793524 rs10979858 rs7859962 rs10116806 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. |
| Mouse PG classification | NA |
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