| Gene Information | |
|---|---|
| Gene Name | POSTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 836 |
| Protein Names | Periostin (PN) (Osteoblast-specific factor 2) (OSF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000133110 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q15063 |
| Gene Card | POSTN |
| Uniprot ID | Q15063 |
| Pfam | PF02469 |
| In ASD | no |
| Allosteric Prediction | yes (0.406346345) |
| Ortholog in Animals | Alpaca_ POSTN ( ortholog_one2one ) Dog_ POSTN ( ortholog_one2one ) GuineaPig_ POSTN ( ortholog_one2one ) Macaque_ POSTN ( ortholog_one2one ) Mouse_ Postn ( ortholog_one2one ) Pig_ POSTN ( ortholog_one2one ) Rat_ Postn ( ortholog_one2one ) Rabbit_ POSTN ( ortholog_one2one ) |
| Ohnologs | TGFBI |
| Paralogs | TGFBI |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. {ECO:0000269|PubMed:11550156, ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:15082792, ECO:0000269|PubMed:23946676}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5WT7 (NMR - ) 5YJG (X-ray 2.40A ) 5YJH (X-ray 2.96A ) |
| DBSNP | rs9594223 rs9547952 |
| Subcellular location [CC] | Golgi apparatus {ECO:0000250|UniProtKB:Q62009}. Secreted {ECO:0000269|PubMed:18450759, ECO:0000269|PubMed:26273833}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12235007, ECO:0000269|PubMed:18450759}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250|UniProtKB:Q62009}. |
| Mouse PG classification | NA |
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