| Gene Information | |
|---|---|
| Gene Name | CRTC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000140577 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6UUV7 |
| Gene Card | CRTC3 |
| Uniprot ID | Q6UUV7 |
| Pfam | PF12886; PF12885; PF12884 |
| In ASD | no |
| Allosteric Prediction | no (-0.403266755) |
| Ortholog in Animals | Alpaca_ CRTC3 ( ortholog_one2one ) GuineaPig_ CRTC3 ( ortholog_one2one ) Macaque_ CRTC3 ( ortholog_one2one ) Mouse_ Crtc3 ( ortholog_one2one ) Pig_ CRTC3 ( ortholog_one2one ) Rat_ Crtc3 ( ortholog_one2one ) Rabbit_ CRTC3 ( ortholog_one2one ) |
| Ohnologs | CRTC1, CRTC2 |
| Paralogs | CRTC1, CRTC2 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:16980408}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8033595 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Cytoplasm {ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Note=Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:30611118}. |
| Mouse PG classification | NA |
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