| Gene Information | |
|---|---|
| Gene Name | PTPN12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 780 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) |
| Target Name | tyrosine-protein phosphatase non-receptor type 12 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000127947 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q05209 |
| Gene Card | PTPN12 |
| Uniprot ID | Q05209 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.40125469) |
| Ortholog in Animals | Alpaca_ PTPN12 ( ortholog_one2one ) Dog_ PTPN12 ( ortholog_one2one ) Macaque_ PTPN12 ( ortholog_one2one ) Mouse_ Ptpn12 ( ortholog_one2one ) Pig_ PTPN12 ( ortholog_one2one ) Rat_ Ptpn12 ( ortholog_one2one ) Rabbit_ PTPN12 ( ortholog_one2one ) |
| Ohnologs | PTPN22 |
| Paralogs | PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002323(Rat);0.023529(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5HDE (X-ray 1.62A ) 5J8R (X-ray 2.04A ) 5O2P (NMR - ) |
| DBSNP | rs121434623 rs9640663 rs3750050 rs2230602 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269|PubMed:18559503}. |
| Mouse PG classification | LPG |
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