Gene Information

Gene Information
Gene Name	PTPN1
Organism	Homo sapiens (Human)
Gene Length	435
Protein Names	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Target Name	protein-tyrosine phosphatase 1b
Target Type	Clinical trial target
Gene Age	645 ( ENSG00000196396 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	P18031
Gene Card	PTPN1
Uniprot ID	P18031
Pfam	PF00102
In ASD	yes
Allosteric Prediction	yes (1.069072436)
Ortholog in Animals	Alpaca_ PTPN1 ( ortholog_one2one ) Dog_ PTPN1 ( ortholog_one2one ) GuineaPig_ PTPN1 ( ortholog_one2one ) Macaque_ PTPN1 ( ortholog_one2one ) Mouse_ Ptpn1 ( ortholog_one2one ) Pig_ PTPN1 ( ortholog_one2one ) Rat_ Ptpn1 ( ortholog_one2one ) Rabbit_ PTPN1 ( ortholog_one2one )
Ohnologs	PTPN2
Paralogs	PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21
Tissue	NA
Tissue Specificity	Expressed in keratinocytes (at protein level). {ECO:0000269\|PubMed:29043977}.
Pharmacological Animal Models	0.000730(Chimpanzee);0.047317(Mouse);0.002419(Rat);0.020000(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1A5Y (X-ray 2.50A ) 1AAX (X-ray 1.90A ) 1BZC (X-ray 2.35A ) 1BZH (X-ray 2.10A ) 1BZJ (X-ray 2.25A ) 1C83 (X-ray 1.80A ) 1C84 (X-ray 2.35A ) 1C85 (X-ray 2.72A ) 1C86 (X-ray 2.30A ) 1C87 (X-ray 2.10A ) 1C88 (X-ray 1.80A ) 1ECV (X-ray 1.95A ) 1EEN (X-ray 1.90A ) 1EEO (X-ray 1.80A ) 1G1F (X-ray 2.00A ) 1G1G (X-ray 2.20A ) 1G1H (X-ray 2.40A ) 1G7F (X-ray 1.80A ) 1G7G (X-ray 2.20A ) 1GFY (X-ray 2.13A ) 1I57 (X-ray 2.10A ) 1JF7 (X-ray 2.20A ) 1KAK (X-ray 2.50A ) 1KAV (X-ray 2.35A ) 1L8G (X-ray 2.50A ) 1LQF (X-ray 2.50A ) 1NL9 (X-ray 2.40A ) 1NNY (X-ray 2.40A ) 1NO6 (X-ray 2.40A ) 1NWE (X-ray 3.10A ) 1NWL (X-ray 2.40A ) 1NZ7 (X-ray 2.40A ) 1OEM (X-ray 1.80A ) 1OEO (X-ray 2.15A ) 1OES (X-ray 2.20A ) 1OET (X-ray 2.30A ) 1OEU (X-ray 2.50A ) 1OEV (X-ray 2.20A ) 1ONY (X-ray 2.15A ) 1ONZ (X-ray 2.40A ) 1PA1 (X-ray 1.60A ) 1PH0 (X-ray 2.20A ) 1PTT (X-ray 2.90A ) 1PTU (X-ray 2.60A ) 1PTV (X-ray 2.30A ) 1PTY (X-ray 1.85A ) 1PXH (X-ray 2.15A ) 1PYN (X-ray 2.20A ) 1Q1M (X-ray 2.60A ) 1Q6J (X-ray 2.20A ) 1Q6M (X-ray 2.20A ) 1Q6N (X-ray 2.10A ) 1Q6P (X-ray 2.30A ) 1Q6S (X-ray 2.20A ) 1Q6T (X-ray 2.30A ) 1QXK (X-ray 2.30A ) 1SUG (X-ray 1.95A ) 1T48 (X-ray 2.20A ) 1T49 (X-ray 1.90A ) 1T4J (X-ray 2.70A ) 1WAX (X-ray 2.20A ) 1XBO (X-ray 2.50A ) 2AZR (X-ray 2.00A ) 2B07 (X-ray 2.10A ) 2B4S (X-ray 2.30A ) 2BGD (X-ray 2.40A ) 2BGE (X-ray 1.80A ) 2CM2 (X-ray 1.50A ) 2CM3 (X-ray 2.10A ) 2CM7 (X-ray 2.10A ) 2CM8 (X-ray 2.10A ) 2CMA (X-ray 2.30A ) 2CMB (X-ray 1.70A ) 2CMC (X-ray 2.20A ) 2CNE (X-ray 1.80A ) 2CNF (X-ray 2.20A ) 2CNG (X-ray 1.90A ) 2CNH (X-ray 1.80A ) 2CNI (X-ray 2.00A ) 2F6F (X-ray 2.00A ) 2F6T (X-ray 1.70A ) 2F6V (X-ray 1.70A ) 2F6W (X-ray 2.20A ) 2F6Y (X-ray 2.15A ) 2F6Z (X-ray 1.70A ) 2F70 (X-ray 2.12A ) 2F71 (X-ray 1.55A ) 2FJM (X-ray 2.10A ) 2FJN (X-ray 2.20A ) 2H4G (X-ray 2.50A ) 2H4K (X-ray 2.30A ) 2HB1 (X-ray 2.00A ) 2HNP (X-ray 2.85A ) 2HNQ (X-ray 2.85A ) 2NT7 (X-ray 2.10A ) 2NTA (X-ray 2.10A ) 2QBP (X-ray 2.50A ) 2QBQ (X-ray 2.10A ) 2QBR (X-ray 2.30A ) 2QBS (X-ray 2.10A ) 2VEU (X-ray 2.40A ) 2VEV (X-ray 1.80A ) 2VEW (X-ray 2.00A ) 2VEX (X-ray 2.20A ) 2VEY (X-ray 2.20A ) 2ZMM (X-ray 2.10A ) 2ZN7 (X-ray 2.10A ) 3A5J (X-ray 1.70A ) 3A5K (X-ray 1.85A ) 3CWE (X-ray 1.60A ) 3D9C (X-ray 2.30A ) 3EAX (X-ray 1.90A ) 3EB1 (X-ray 2.40A ) 3EU0 (X-ray 2.70A ) 3I7Z (X-ray 2.30A ) 3I80 (X-ray 2.25A ) 3QKP (X-ray 2.05A ) 3QKQ (X-ray 2.20A ) 3SME (X-ray 1.70A ) 3ZMP (X-ray 2.62A ) 3ZMQ (X-ray 3.30A ) 3ZV2 (X-ray 2.80A ) 4BJO (X-ray 2.06A ) 4I8N (X-ray 2.50A ) 4QAH (X-ray 2.40A ) 4QAP (X-ray 1.90A ) 4QBE (X-ray 2.29A ) 4QBW (X-ray 1.91A ) 4Y14 (X-ray 1.90A ) 4ZRT (X-ray 1.74A ) 5K9V (X-ray 1.90A ) 5K9W (X-ray 2.01A ) 5KA0 (X-ray 1.99A ) 5KA1 (X-ray 1.84A ) 5KA2 (X-ray 2.07A ) 5KA3 (X-ray 2.14A ) 5KA4 (X-ray 2.19A ) 5KA7 (X-ray 2.06A ) 5KA8 (X-ray 1.97A ) 5KA9 (X-ray 2.07A ) 5KAA (X-ray 1.97A ) 5KAB (X-ray 1.97A ) 5KAC (X-ray 1.90A ) 5KAD (X-ray 1.90A ) 5QDE (X-ray 1.76A ) 5QDF (X-ray 1.71A ) 5QDG (X-ray 1.79A ) 5QDH (X-ray 1.68A ) 5QDI (X-ray 1.62A ) 5QDJ (X-ray 1.76A ) 5QDK (X-ray 1.55A ) 5QDL (X-ray 1.83A ) 5QDM (X-ray 2.65A ) 5QDN (X-ray 1.82A ) 5QDO (X-ray 1.79A ) 5QDP (X-ray 1.74A ) 5QDQ (X-ray 1.57A ) 5QDR (X-ray 1.78A ) 5QDS (X-ray 1.75A ) 5QDT (X-ray 1.82A ) 5QDU (X-ray 1.67A ) 5QDV (X-ray 1.77A ) 5QDW (X-ray 2.21A ) 5QDX (X-ray 2.06A ) 5QDY (X-ray 1.83A ) 5QDZ (X-ray 2.14A ) 5QE0 (X-ray 1.98A ) 5QE1 (X-ray 1.69A ) 5QE2 (X-ray 1.79A ) 5QE3 (X-ray 1.74A ) 5QE4 (X-ray 1.85A ) 5QE5 (X-ray 1.77A ) 5QE6 (X-ray 1.77A ) 5QE7 (X-ray 1.71A ) 5QE8 (X-ray 1.81A ) 5QE9 (X-ray 1.69A ) 5QEA (X-ray 1.74A ) 5QEB (X-ray 1.73A ) 5QEC (X-ray 1.67A ) 5QED (X-ray 1.75A ) 5QEE (X-ray 1.93A ) 5QEF (X-ray 1.60A ) 5QEG (X-ray 1.97A ) 5QEH (X-ray 1.94A ) 5QEI (X-ray 1.74A ) 5QEJ (X-ray 1.92A ) 5QEK (X-ray 1.90A ) 5QEL (X-ray 1.65A ) 5QEM (X-ray 1.75A ) 5QEN (X-ray 1.77A ) 5QEO (X-ray 1.72A ) 5QEP (X-ray 1.77A ) 5QEQ (X-ray 1.97A ) 5QER (X-ray 1.73A ) 5QES (X-ray 1.75A ) 5QET (X-ray 1.72A ) 5QEU (X-ray 1.74A ) 5QEV (X-ray 1.72A ) 5QEW (X-ray 1.83A ) 5QEX (X-ray 1.67A ) 5QEY (X-ray 1.77A ) 5QEZ (X-ray 1.65A ) 5QF0 (X-ray 1.71A ) 5QF1 (X-ray 1.84A ) 5QF2 (X-ray 1.77A ) 5QF3 (X-ray 1.56A ) 5QF4 (X-ray 1.83A ) 5QF5 (X-ray 1.73A ) 5QF6 (X-ray 1.76A ) 5QF7 (X-ray 1.75A ) 5QF8 (X-ray 1.99A ) 5QF9 (X-ray 1.94A ) 5QFA (X-ray 1.74A ) 5QFB (X-ray 1.85A ) 5QFC (X-ray 1.84A ) 5QFD (X-ray 1.69A ) 5QFE (X-ray 1.56A ) 5QFF (X-ray 1.70A ) 5QFG (X-ray 1.65A ) 5QFH (X-ray 1.59A ) 5QFI (X-ray 1.68A ) 5QFJ (X-ray 1.95A ) 5QFK (X-ray 1.59A ) 5QFL (X-ray 1.82A ) 5QFM (X-ray 1.83A ) 5QFN (X-ray 1.68A ) 5QFO (X-ray 1.85A ) 5QFP (X-ray 1.77A ) 5QFQ (X-ray 1.62A ) 5QFR (X-ray 1.62A ) 5QFS (X-ray 1.85A ) 5QFT (X-ray 1.96A ) 5QFU (X-ray 1.61A ) 5QFV (X-ray 1.64A ) 5QFW (X-ray 1.66A ) 5QFX (X-ray 1.82A ) 5QFY (X-ray 1.77A ) 5QFZ (X-ray 1.72A ) 5QG0 (X-ray 1.75A ) 5QG1 (X-ray 2.21A ) 5QG2 (X-ray 2.12A ) 5QG3 (X-ray 1.65A ) 5QG4 (X-ray 1.79A ) 5QG5 (X-ray 2.07A ) 5QG6 (X-ray 1.73A ) 5QG7 (X-ray 1.81A ) 5QG8 (X-ray 1.63A ) 5QG9 (X-ray 1.67A ) 5QGA (X-ray 1.65A ) 5QGB (X-ray 1.55A ) 5QGC (X-ray 1.59A ) 5QGD (X-ray 1.66A ) 5QGE (X-ray 1.70A ) 5QGF (X-ray 1.51A ) 5T19 (X-ray 2.10A ) 6B8E (X-ray 1.82A ) 6B8T (X-ray 1.85A ) 6B8X (X-ray 1.74A ) 6B8Z (X-ray 1.80A ) 6B90 (X-ray 1.95A ) 6B95 (X-ray 1.95A ) 6BAI (X-ray 1.95A ) 6CWU (X-ray 2.08A ) 6CWV (X-ray 1.98A ) 6NTP (X-ray 1.89A ) 6OL4 (X-ray 2.15A ) 6OLQ (X-ray 2.10A ) 6OLV (X-ray 2.10A ) 6OMY (X-ray 2.10A ) 6PFW (X-ray 2.34A ) 6PG0 (X-ray 2.10A ) 6PGT (X-ray 2.20A ) 6PHA (X-ray 2.30A ) 6PHS (X-ray 2.13A ) 6PM8 (X-ray 2.06A ) 6W30 (X-ray 2.10A ) 6XE8 (X-ray 1.95A ) 6XEA (X-ray 1.55A ) 6XED (X-ray 1.79A ) 6XEE (X-ray 2.50A ) 6XEF (X-ray 2.05A ) 6XEG (X-ray 2.55A ) 7KEN (X-ray 1.80A ) 7KEY (X-ray 1.77A ) 7KLX (X-ray 1.84A ) 7L0C (X-ray 1.80A ) 7L0H (X-ray 2.10A ) 7LFO (X-ray 1.94A ) 7MKZ (X-ray 1.40A ) 7MM1 (X-ray 1.85A ) 7MN7 (X-ray 1.95A ) 7MN9 (X-ray 1.24A ) 7MNA (X-ray 1.47A ) 7MNB (X-ray 2.20A ) 7MNC (X-ray 1.85A ) 7MND (X-ray 2.29A ) 7MNE (X-ray 1.60A ) 7MNF (X-ray 1.70A ) 7MOU (X-ray 1.48A ) 7MOV (X-ray 1.65A ) 7MOW (X-ray 1.80A ) 7RIN (X-ray 1.85A ) 8DU7 (X-ray 2.40A )
DBSNP	rs16995304 rs16995309
Subcellular location [CC]	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:1739967, ECO:0000269\|PubMed:21135139}; Peripheral membrane protein {ECO:0000269\|PubMed:1739967, ECO:0000269\|PubMed:21135139}; Cytoplasmic side {ECO:0000269\|PubMed:1739967, ECO:0000269\|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Mouse PG classification	NA
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