| Gene Information | |
|---|---|
| Gene Name | PTP4A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 167 |
| Protein Names | Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000184007 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q12974 |
| Gene Card | PTP4A2 |
| Uniprot ID | Q12974 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | no (-1.039237006) |
| Ortholog in Animals | Alpaca_ PTP4A2 ( ortholog_one2one ) Dog_ PTP4A2 ( ortholog_one2one ) Macaque_ PTP4A2 ( ortholog_one2one ) Mouse_ Ptp4a2 ( ortholog_one2one ) Pig_ PTP4A2 ( ortholog_one2one ) Rat_ Ptp4a2 ( ortholog_one2one ) Rabbit_ PTP4A2 ( ortholog_one2one ) |
| Ohnologs | PTP4A1, PTP4A3 |
| Paralogs | CDC14A, PTP4A3, CDC14B, CDC14C, PTP4A1, CDKN3, PTPDC1, PALD1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:11734337, ECO:0000269|PubMed:8661118}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5K22 (X-ray 3.00A ) 5K23 (X-ray 2.96A ) 5K25 (X-ray 3.05A ) 6WUR (X-ray 2.88A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane. Early endosome. Cytoplasm. |
| Mouse PG classification | NA |
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