| Gene Information | |
|---|---|
| Gene Name | PTP1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 2485 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q12923 |
| Gene Card | PTPN13 |
| Uniprot ID | Q12923 |
| Pfam | PF09380; PF00373; PF09379; PF00595; PF00102 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. {ECO:0000269|PubMed:29043977}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1D5G (NMR - ) 1Q7X (NMR - ) 1WCH (X-ray 1.85A ) 2M0Z (NMR - ) 2M10 (NMR - ) 3LNX (X-ray 1.64A ) 3LNY (X-ray 1.30A ) 3PDZ (NMR - ) 5GLJ (X-ray 1.60A ) 7QCX (NMR - ) 7QCY (NMR - ) |
| DBSNP | rs10033029 rs749353184 rs2230600 rs12500797 rs17012064 rs989902 rs34226837 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. |
| Mouse PG classification | NA |
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