| Gene Information | |
|---|---|
| Gene Name | PTP1C |
| Organism | Homo sapiens (Human) |
| Gene Length | 595 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P29350 |
| Gene Card | PTPN6 |
| Uniprot ID | P29350 |
| Pfam | PF00017; PF00102 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FPR (X-ray 2.50A ) 1GWZ (X-ray 2.50A ) 1X6C (NMR - ) 2B3O (X-ray 2.80A ) 2RMX (NMR - ) 2YU7 (NMR - ) 3PS5 (X-ray 3.10A ) 4GRY (X-ray 1.70A ) 4GRZ (X-ray 1.37A ) 4GS0 (X-ray 1.80A ) 4HJP (X-ray 1.40A ) 4HJQ (X-ray 1.80A ) 6SM5 (X-ray 2.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. {ECO:0000250}. |
| Mouse PG classification | NA |
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