| Gene Information | |
|---|---|
| Gene Name | PTK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1052 |
| Protein Names | Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) |
| Target Name | focal adhesion kinase 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000169398 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q05397 |
| Gene Card | PTK2 |
| Uniprot ID | Q05397 |
| Pfam | PF00373; PF18038; PF03623; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.009588839) |
| Ortholog in Animals | Alpaca_ PTK2 ( ortholog_one2one ) Dog_ PTK2 ( ortholog_one2one ) GuineaPig_ PTK2 ( ortholog_one2one ) Macaque_ PTK2 ( ortholog_one2one ) Mouse_ Ptk2 ( ortholog_one2one ) Pig_ PTK2 ( ortholog_one2one ) Rat_ Ptk2 ( ortholog_one2one ) Rabbit_ PTK2 ( ortholog_one2one ) |
| Ohnologs | PTK2B |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous. Expressed in epithelial cells (at protein level) (PubMed:31630787). {ECO:0000269|PubMed:20109444, ECO:0000269|PubMed:31630787, ECO:0000269|PubMed:7692878, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:8422239}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1K04 (X-ray 1.95A ) 1K05 (X-ray 2.90A ) 1MP8 (X-ray 1.60A ) 1OW6 (X-ray 2.35A ) 1OW7 (X-ray 2.60A ) 1OW8 (X-ray 2.85A ) 2ETM (X-ray 2.30A ) 2IJM (X-ray 2.19A ) 3B71 (X-ray 2.82A ) 3BZ3 (X-ray 2.20A ) 3PXK (X-ray 1.79A ) 3S9O (X-ray 2.60A ) 4EBV (X-ray 1.67A ) 4EBW (X-ray 2.65A ) 4GU6 (X-ray 1.95A ) 4GU9 (X-ray 2.40A ) 4I4E (X-ray 1.55A ) 4I4F (X-ray 1.75A ) 4K8A (X-ray 2.91A ) 4K9Y (X-ray 2.00A ) 4KAB (X-ray 2.71A ) 4KAO (X-ray 2.39A ) 4NY0 (X-ray 2.80A ) 4Q9S (X-ray 2.07A ) 6I8Z (X-ray 1.99A ) 6LES (X-ray 2.00A ) 6PW8 (X-ray 1.95A ) 6YOJ (X-ray 1.36A ) 6YQ1 (X-ray 1.78A ) 6YR9 (X-ray 1.93A ) 6YT6 (X-ray 1.54A ) 6YVS (X-ray 1.81A ) 6YVY (X-ray 1.92A ) 6YXV (X-ray 2.30A ) 7PI4 (X-ray 2.24A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:31630787}. Cell membrane {ECO:0000250|UniProtKB:Q00944}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q00944}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00944}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15855171}. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O35346}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus {ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18206965}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:31630787}. Cytoplasm {ECO:0000269|PubMed:15855171, ECO:0000269|PubMed:18078954, ECO:0000269|PubMed:18206965, ECO:0000269|PubMed:18256281}. Note=Constituent of focal adhesions. Detected at microtubules. {ECO:0000250|UniProtKB:P34152}. |
| Mouse PG classification | NA |
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