| Gene Information | |
|---|---|
| Gene Name | ADRA1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor) |
| Target Name | adrenergic receptor alpha-1b |
| Target Type | Successful target |
| Gene Age | 886 ( ENSG00000170214 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35368 |
| Gene Card | ADRA1B |
| Uniprot ID | P35368 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.693582956) |
| Ortholog in Animals | Alpaca_ ADRA1B ( ortholog_one2one ) Dog_ ADRA1B ( ortholog_one2one ) GuineaPig_ ADRA1B ( ortholog_one2one ) Macaque_ ADRA1B ( ortholog_one2one ) Mouse_ Adra1b ( ortholog_one2one ) Pig_ ADRA1B ( ortholog_one2one ) Rat_ Adra1b ( ortholog_one2one ) Rabbit_ ADRA1B ( ortholog_one2one ) |
| Ohnologs | ADRA1A, HTR1B, HTR7, ADRA1D, HTR1A, DRD5 |
| Paralogs | OR56A4, ADRA2A, ADRB2, ADRA2B, OR56A1, OR56A3, OR56A5, DRD2, ADRB3, ADRA1D, OR5T2, OR5T3, OR5T1, ADRA1A, GPR101, ADRB1, OR13F1, ADRA2C |
| Tissue | brain, spleen, cerebral.cortex, aorta, tibial.artery |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8192448 |
| Subcellular location [CC] | Nucleus membrane; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:24567387}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:24567387}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. |
| Mouse PG classification | NA |
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