| Gene Information | |
|---|---|
| Gene Name | PACC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 350 |
| Protein Names | Proton-activated chloride channel (PAC) (hPAC) (Acid-sensitive outwardly-rectifying anion channel) (ASOR) (Proton-activated outwardly rectifying anion channel) (PAORAC) (Transmembrane protein 206) (hTMEM206) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000065600 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9H813 |
| Gene Card | PACC1 |
| Uniprot ID | Q9H813 |
| Pfam | PF15122 |
| In ASD | no |
| Allosteric Prediction | no (-0.960817059) |
| Ortholog in Animals | Alpaca_ PACC1 ( ortholog_one2one ) Dog_ PACC1 ( ortholog_one2one ) GuineaPig_ PACC1 ( ortholog_one2one ) Macaque_ PACC1 ( ortholog_one2one ) Mouse_ Pacc1 ( ortholog_one2one ) Pig_ PACC1 ( ortholog_one2one ) Rat_ Pacc1 ( ortholog_one2one ) Rabbit_ PACC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:31023925}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7JNA (EM 3.60A ) 7JNC (EM 3.73A ) 7SQF (EM 3.10A ) 7SQG (EM 2.60A ) 7SQH (EM 2.50A ) |
| DBSNP | rs1034429230 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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