| Gene Information | |
|---|---|
| Gene Name | PTGS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 599 |
| Protein Names | Prostaglandin G/H synthase 1 (EC 1.14.99.1) (Cyclooxygenase-1) (COX-1) (Prostaglandin H2 synthase 1) (PGH synthase 1) (PGHS-1) (PHS 1) (Prostaglandin-endoperoxide synthase 1) |
| Target Name | prostaglandin g/h synthase 1 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000095303 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P23219 |
| Gene Card | PTGS1 |
| Uniprot ID | P23219 |
| Pfam | PF03098; PF00008 |
| In ASD | yes |
| Allosteric Prediction | yes (1.224970287) |
| Ortholog in Animals | Alpaca_ PTGS1 ( ortholog_one2one ) Dog_ PTGS1 ( ortholog_one2one ) GuineaPig_ PTGS1 ( ortholog_one2one ) Macaque_ PTGS1 ( ortholog_one2one ) Mouse_ Ptgs1 ( ortholog_one2one ) Pig_ PTGS1 ( ortholog_one2one ) Rat_ Ptgs1 ( ortholog_one2one ) Rabbit_ PTGS1 ( ortholog_one2one ) |
| Ohnologs | PTGS2 |
| Paralogs | PTGS2 |
| Tissue | sigmoid.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6Y3C (X-ray 3.36A ) |
| DBSNP | rs1236913 rs3842787 rs3842789 rs10306140 rs3842792 rs5789 rs3842799 rs5791 rs5792 rs5794 |
| Subcellular location [CC] | Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. |
| Mouse PG classification | NA |
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