| Gene Information | |
|---|---|
| Gene Name | PTGER3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor) |
| Target Name | prostaglandin e2 receptor ep3 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000050628 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43115 |
| Gene Card | PTGER3 |
| Uniprot ID | P43115 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.287690035) |
| Ortholog in Animals | Alpaca_ PTGER3 ( ortholog_one2one ) Dog_ PTGER3 ( ortholog_one2one ) GuineaPig_ PTGER3 ( ortholog_one2one ) Macaque_ PTGER3 ( ortholog_one2one ) Mouse_ Ptger3 ( ortholog_one2one ) Pig_ PTGER3 ( ortholog_one2one ) Rat_ Ptger3 ( ortholog_one2one ) Rabbit_ PTGER3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTGFR, TBXA2R, PTGER1, PTGER2, PTGDR, PTGIR, PTGER4 |
| Tissue | adipose.tissue, kidney, uterus |
| Tissue Specificity | Detected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. {ECO:0000269|PubMed:18023986, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8135729}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6AK3 (X-ray 2.90A ) 6M9T (X-ray 2.50A ) 7WU9 (EM 3.38A ) |
| DBSNP | rs5670 rs13306020 rs13306014 rs5694 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8307176}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |