Gene Information
Gene NameARPP21
OrganismHomo sapiens (Human)
Gene Length812
Protein NamescAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000172995 )
Evolutionary StageEukaryota
AlphaFoldDBQ9UBL0
Gene CardARPP21
Uniprot IDQ9UBL0
PfamPF01424; PF12752
In ASDno
Allosteric Predictionno (-0.749971172)
Ortholog in AnimalsAlpaca_ ARPP21 ( ortholog_one2one )
Dog_ ARPP21 ( ortholog_one2one )
GuineaPig_ ARPP21 ( ortholog_one2one )
Macaque_ ARPP21 ( ortholog_one2one )
Mouse_ Arpp21 ( ortholog_one2one )
Pig_ ARPP21 ( ortholog_one2one )
Rat_ Arpp21 ( ortholog_one2one )
Rabbit_ ARPP21 ( ortholog_one2one )
OhnologsR3HDM2, R3HDM1
ParalogsR3HDM1, R3HDM2
Tissuebrain, cerebral.cortex, caudate.nucleus, nucleus.accumbens, putamen
Tissue SpecificityIsoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO:0000269|PubMed:15096520, ECO:0000269|PubMed:8120638}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000250}.
Mouse PG classificationNA
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