| Gene Information | |
|---|---|
| Gene Name | CMTM6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 183 |
| Protein Names | CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000091317 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NX76 |
| Gene Card | CMTM6 |
| Uniprot ID | Q9NX76 |
| Pfam | PF01284 |
| In ASD | no |
| Allosteric Prediction | no (-0.887438617) |
| Ortholog in Animals | Alpaca_ CMTM6 ( ortholog_one2one ) Dog_ CMTM6 ( ortholog_one2one ) GuineaPig_ CMTM6 ( ortholog_one2one ) Macaque_ CMTM6 ( ortholog_one2one ) Mouse_ Cmtm6 ( ortholog_one2one ) Rat_ Cmtm6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CMTM2, PLP2, MAL, CMTM3, PLLP, CMTM4, CMTM8, CMTM1, MAL2, CMTM7, CKLF, MALL, MARVELD1, CMTM5 |
| Tissue | NA |
| Tissue Specificity | Expressed in the leukocytes, placenta and testis. {ECO:0000269|PubMed:12782130}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35574803 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:28813417}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with PD-L1/CD274 in the plasma membrane and in recycling endosomes. {ECO:0000269|PubMed:28813417}. |
| Mouse PG classification | NA |
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