| Gene Information | |
|---|---|
| Gene Name | PAD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 694 |
| Protein Names | Protein-arginine deiminase type-6 (EC 3.5.3.15) (Peptidyl arginine deiminase-like protein) (Peptidylarginine deiminase VI) (hPADVI) (Protein-arginine deiminase type VI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q6TGC4 |
| Gene Card | PADI6 |
| Uniprot ID | Q6TGC4 |
| Pfam | PF03068; PF08527; PF08526 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in oocytes and weakly expressed in other somatic tissues. {ECO:0000269|PubMed:15625577, ECO:0000269|PubMed:27545678}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4DAT (X-ray 1.40A ) 4DAU (X-ray 2.00A ) |
| DBSNP | rs775156958 rs1057517684 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:27545678}. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development. {ECO:0000250|UniProtKB:Q8K3V4}. |
| Mouse PG classification | NA |
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