Gene Information
Gene NameC1QBP
OrganismHomo sapiens (Human)
Gene Length282
Protein NamesComplement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33) (SF2AP32)
Target Namecomplement component 1 q subcomponent-binding protein, mitochondrial
Target TypeNA
Gene Age680 ( ENSG00000108561 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ07021
Gene CardC1QBP
Uniprot IDQ07021
PfamPF02330
In ASDno
Allosteric Predictionyes (0.378973669)
Ortholog in AnimalsAlpaca_ C1QBP ( ortholog_one2one )
GuineaPig_ C1QBP ( ortholog_one2one )
Macaque_ C1QBP ( ortholog_one2one )
Mouse_ C1qbp ( ortholog_one2one )
Pig_ C1QBP ( ortholog_one2one )
Rat_ C1qbp ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed on cell surface of peripheral blood cells (at protein level);
Surface expression is reported for macrophages and monocyte-derived dendritic cells. {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002043(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1P32  (X-ray  2.25A  )  3RPX  (X-ray  2.65A  )  6SZW  (X-ray  3.14A  )  7TE3  (X-ray  2.20A  ) 
DBSNP rs748497469  rs755568057  rs767427194  rs1394499137  rs1555532484  rs1555532483 
Subcellular location [CC]Mitochondrion matrix {ECO:0000269|PubMed:15031724, ECO:0000269|PubMed:17486078, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:9305894}. Nucleus {ECO:0000269|PubMed:18676636}. Nucleus, nucleolus {ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:32958672}. Cell membrane {ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:11493647, ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8195709, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880, ECO:0000269|PubMed:9233640};
Peripheral membrane protein {ECO:0000269|PubMed:12574814, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:9191880};
Extracellular side. Secreted. Cytoplasm {ECO:0000269|PubMed:11493647}. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). {ECO:0000269|PubMed:32958672}.
Mouse PG classificationNA
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