| Gene Information | |
|---|---|
| Gene Name | PTCH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1447 |
| Protein Names | Protein patched homolog 1 (PTC) (PTC1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13635 |
| Gene Card | PTCH1 |
| Uniprot ID | Q13635 |
| Pfam | PF02460; PF12349 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001516(Rat);0.02(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6DMB (EM 3.90A ) 6DMO (EM 4.10A ) 6DMY (EM 3.60A ) 6E1H (EM 3.50A ) 6N7G (EM 6.80A ) 6N7H (EM 3.60A ) 6N7K (EM 6.50A ) 6OEU (EM 3.50A ) 6OEV (EM 3.80A ) 6RMG (EM 3.40A ) 6RTW (X-ray 1.90A ) 6RTX (X-ray 1.95A ) 6RTY (X-ray 2.10A ) 6RVC (X-ray 2.20A ) 6RVD (EM 3.50A ) |
| DBSNP | rs199476091 rs878853845 rs115556836 rs199476092 rs201125580 rs199476093 rs138911275 rs587776689 rs878853856 rs2236405 rs779417284 rs2227968 rs357564 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q61115}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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