| Gene Information | |
|---|---|
| Gene Name | VCAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 739 |
| Protein Names | Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) |
| Target Name | vascular cell adhesion protein 1 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000162692 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19320 |
| Gene Card | VCAM1 |
| Uniprot ID | P19320 |
| Pfam | PF05790; PF07679; PF00047 |
| In ASD | no |
| Allosteric Prediction | yes (1.166383196) |
| Ortholog in Animals | Alpaca_ VCAM1 ( ortholog_one2one ) Dog_ VCAM1 ( ortholog_one2one ) GuineaPig_ VCAM1 ( ortholog_one2one ) Macaque_ VCAM1 ( ortholog_one2one ) Mouse_ Vcam1 ( ortholog_one2one ) Pig_ VCAM1 ( ortholog_one2one ) Rat_ Vcam1 ( ortholog_one2one ) Rabbit_ VCAM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CNTN5, CNTN2, NFASC, ROBO2, SDK1, SDK2, CNTN3, HMCN2, CNTN6, DSCAML1, VSIG10L, CNTN1, IGDCC4, IGSF21, ROBO1, L1CAM, BOC, DCC, IGDCC3, ROBO4, IGSF9, VSIG10, DSCAM, CDON, NCAM1, ROBO3, CHL1, NRCAM, NEO1, IGSF9B, MXRA5, IGSF10, PTPRQ, NCAM2, PRTG, CNTN4 |
| Tissue | NA |
| Tissue Specificity | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1IJ9 (X-ray 3.00A ) 1VCA (X-ray 1.80A ) 1VSC (X-ray 1.90A ) |
| DBSNP | rs34228330 rs3783611 rs3783612 rs3783613 rs34100871 rs34199378 rs3783615 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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