| Gene Information | |
|---|---|
| Gene Name | TMEM115 |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | Transmembrane protein 115 (Placental protein 6) (Protein PL6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000126062 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12893 |
| Gene Card | TMEM115 |
| Uniprot ID | Q12893 |
| Pfam | PF08551 |
| In ASD | no |
| Allosteric Prediction | no (-0.834542012) |
| Ortholog in Animals | Alpaca_ TMEM115 ( ortholog_one2one ) Dog_ TMEM115 ( ortholog_one2one ) GuineaPig_ TMEM115 ( ortholog_one2one ) Macaque_ TMEM115 ( ortholog_one2one ) Mouse_ Tmem115 ( ortholog_one2one ) Pig_ TMEM115 ( ortholog_one2one ) Rat_ Tmem115 ( ortholog_one2one ) Rabbit_ TMEM115 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed strongly in kidney and skeletal muscle, followed by liver, placenta, pancreas, and lung, with low amounts in heart and only traces in brain (PubMed:11085536). Widely expressed with ubiquitous expression in epithelial tissues (at protein level) (PubMed:17973242). {ECO:0000269|PubMed:11085536, ECO:0000269|PubMed:17973242}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:17973242, ECO:0000269|PubMed:24806965}; Multi-pass membrane protein {ECO:0000303|PubMed:24806965}. |
| Mouse PG classification | NA |
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