| Gene Information | |
|---|---|
| Gene Name | PSPC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 523 |
| Protein Names | Paraspeckle component 1 (Paraspeckle protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000121390 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WXF1 |
| Gene Card | PSPC1 |
| Uniprot ID | Q8WXF1 |
| Pfam | PF08075; PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-1.196976602) |
| Ortholog in Animals | Alpaca_ PSPC1 ( ortholog_one2one ) Dog_ PSPC1 ( ortholog_one2one ) GuineaPig_ PSPC1 ( ortholog_one2one ) Macaque_ PSPC1 ( ortholog_one2one ) Mouse_ Pspc1 ( ortholog_one2one ) Pig_ PSPC1 ( ortholog_one2one ) Rat_ Pspc1 ( ortholog_one2one ) Rabbit_ PSPC1 ( ortholog_one2one ) |
| Ohnologs | NONO, SFPQ |
| Paralogs | RAVER2, RBM15B, SPEN, NONO, RAVER1, SFPQ, RBM15 |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. {ECO:0000269|PubMed:11790299}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.006790(Mouse);0.009749(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3SDE (X-ray 1.90A ) 5IFN (X-ray 3.17A ) 5WPA (X-ray 2.29A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. |
| Mouse PG classification | NA |
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