| Gene Information | |
|---|---|
| Gene Name | PROX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 737 |
| Protein Names | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000117707 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q92786 |
| Gene Card | PROX1 |
| Uniprot ID | Q92786 |
| Pfam | PF05044 |
| In ASD | no |
| Allosteric Prediction | no (-0.785948956) |
| Ortholog in Animals | Alpaca_ PROX1 ( ortholog_one2one ) Dog_ PROX1 ( ortholog_one2one ) GuineaPig_ PROX1 ( ortholog_one2one ) Macaque_ PROX1 ( ortholog_one2one ) Mouse_ Prox1 ( ortholog_one2one ) Pig_ PROX1 ( ortholog_one2one ) Rat_ Prox1 ( ortholog_one2one ) Rabbit_ PROX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PROX2 |
| Tissue | liver |
| Tissue Specificity | Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:8812486}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LMD (NMR - ) |
| DBSNP | rs12121210 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}. |
| Mouse PG classification | NA |
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