| Gene Information | |
|---|---|
| Gene Name | SLK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1235 |
| Protein Names | STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2) |
| Target Name | ste20-like serine/threonine-protein kinase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000065613 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9H2G2 |
| Gene Card | SLK |
| Uniprot ID | Q9H2G2 |
| Pfam | PF00069; PF12474 |
| In ASD | no |
| Allosteric Prediction | yes (0.66300721) |
| Ortholog in Animals | Alpaca_ SLK ( ortholog_one2one ) Dog_ SLK ( ortholog_one2one ) GuineaPig_ SLK ( ortholog_one2one ) Macaque_ SLK ( ortholog_one2one ) Mouse_ Slk ( ortholog_one2one ) Pig_ SLK ( ortholog_one2one ) Rat_ Slk ( ortholog_one2one ) Rabbit_ SLK ( ortholog_one2one ) |
| Ohnologs | STK10 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle. {ECO:0000269|PubMed:10699464}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2J51 (X-ray 2.10A ) 2JFL (X-ray 2.20A ) 2JFM (X-ray 2.85A ) 2UV2 (X-ray 2.30A ) 4USF (X-ray 1.75A ) 6HVD (X-ray 1.63A ) |
| DBSNP | rs805657 rs190220654 rs56400929 rs7071400 rs34326537 rs35389916 rs3740469 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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