Gene Information
Gene NameSPPL3
OrganismHomo sapiens (Human)
Gene Length384
Protein NamesSignal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)
Target NameNA
Target TypeNA
Gene Age1064 ( ENSG00000157837 )
Evolutionary StageEukaryota
AlphaFoldDBQ8TCT6
Gene CardSPPL3
Uniprot IDQ8TCT6
PfamPF04258
In ASDno
Allosteric Predictionno (-0.778748275)
Ortholog in AnimalsAlpaca_ SPPL3 ( ortholog_one2one )
Dog_ SPPL3 ( ortholog_one2one )
GuineaPig_ SPPL3 ( ortholog_one2one )
Macaque_ SPPL3 ( ortholog_one2one )
Mouse_ Sppl3 ( ortholog_one2one )
Pig_ SPPL3 ( ortholog_one2one )
Rat_ Sppl3 ( ortholog_one2one )
Rabbit_ SPPL3 ( ortholog_one2one )
OhnologsNA
ParalogsSPPL2B, SPPL2C, SPPL2A, HM13
TissueNA
Tissue SpecificityWidely expressed (PubMed:15385547). Expressed in the brain (PubMed:11978763). {ECO:0000269|PubMed:11978763, ECO:0000269|PubMed:15385547}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Endoplasmic reticulum membrane {ECO:0000269|PubMed:15998642};
Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:16829952}. Membrane {ECO:0000269|PubMed:15385547};
Multi-pass membrane protein {ECO:0000305};
Lumenal side {ECO:0000269|PubMed:15385547}.
Mouse PG classificationNA
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