Gene Information
Gene NamePSME1
OrganismHomo sapiens (Human)
Gene Length249
Protein NamesProteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)
Target Nameproteasome activator complex subunit 1
Target TypeNA
Gene Age454 ( ENSG00000092010 )
3 ( ENSG00000284916 )
Evolutionary StageEukaryota
AlphaFoldDBQ06323
Gene CardPSME1
Uniprot IDQ06323
PfamPF02251; PF02252
In ASDno
Allosteric Predictionyes (0.261823447)
Ortholog in AnimalsAlpaca_ PSME1 ( ortholog_one2one )
Dog_ PSME1 ( ortholog_one2many )
GuineaPig_ PSME1 ( ortholog_one2one )
Macaque_ PSME1 ( ortholog_one2one )
Mouse_ Psme1 ( ortholog_one2one )
Pig_ PSME1 ( ortholog_one2one )
Rat_ Psme1-ps1 ( ortholog_one2many )
Rat_ Psme1 ( ortholog_one2many )
Rabbit_ PSME1 ( ortholog_one2one )
OhnologsNA
ParalogsPSME2, PSME3
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.028951(Chimpanzee);0.044400(Mouse);NULL(Rat);0.048485(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AVO  (X-ray  2.80A  7DR6  (EM  4.10A  7DRW  (EM  4.20A 
DBSNP rs1803830  rs14930 
Subcellular location [CC]NA
Mouse PG classificationNA
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