| Gene Information | |
|---|---|
| Gene Name | ITGAE |
| Organism | Homo sapiens (Human) |
| Gene Length | 1179 |
| Protein Names | Integrin alpha-E (HML-1 antigen) (Integrin alpha-IEL) (Mucosal lymphocyte 1 antigen) (CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000083457 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P38570 |
| Gene Card | ITGAE |
| Uniprot ID | P38570 |
| Pfam | PF01839; PF00357; PF08441; PF00092 |
| In ASD | no |
| Allosteric Prediction | yes (0.090600545) |
| Ortholog in Animals | Alpaca_ ITGAE ( ortholog_one2one ) Dog_ ITGAE ( ortholog_one2one ) GuineaPig_ ITGAE ( ortholog_one2one ) Macaque_ ITGAE ( ortholog_one2one ) Mouse_ Itgae ( ortholog_one2one ) Pig_ ITGAE ( ortholog_one2one ) Rat_ Itgae ( ortholog_one2many ) Rabbit_ ITGAE ( ortholog_one2one ) |
| Ohnologs | ITGAL, ITGAM |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGA2, ITGAD, ITGA5, ITGA6, ITGAV, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | lung |
| Tissue Specificity | Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs220479 rs2272606 rs3744679 rs1716 rs2976230 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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