| Gene Information | |
|---|---|
| Gene Name | GEM |
| Organism | Homo sapiens (Human) |
| Gene Length | 296 |
| Protein Names | GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR) |
| Target Name | ras-like protein kir |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000164949 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55040 |
| Gene Card | GEM |
| Uniprot ID | P55040 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.753205499) |
| Ortholog in Animals | Alpaca_ GEM ( ortholog_one2one ) Dog_ GEM ( ortholog_one2one ) GuineaPig_ GEM ( ortholog_one2one ) Macaque_ GEM ( ortholog_one2one ) Mouse_ Gem ( ortholog_one2one ) Pig_ GEM ( ortholog_one2one ) Rat_ Gem ( ortholog_one2one ) Rabbit_ GEM ( ortholog_one2one ) |
| Ohnologs | REM1, REM2, RRAD |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, DIRAS3, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | NA |
| Tissue Specificity | Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CJW (X-ray 2.10A ) 2G3Y (X-ray 2.40A ) 2HT6 (X-ray 2.40A ) |
| DBSNP | rs2170363 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Mouse PG classification | NA |
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