| Gene Information | |
|---|---|
| Gene Name | ITGAV |
| Organism | Homo sapiens (Human) |
| Gene Length | 1048 |
| Protein Names | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| Target Name | itgav messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000138448 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P06756 |
| Gene Card | ITGAV |
| Uniprot ID | P06756 |
| Pfam | PF01839; PF00357; PF08441 |
| In ASD | yes |
| Allosteric Prediction | yes (1.052753196) |
| Ortholog in Animals | Alpaca_ ITGAV ( ortholog_one2one ) Dog_ ITGAV ( ortholog_one2one ) GuineaPig_ ITGAV ( ortholog_one2one ) Macaque_ ITGAV ( ortholog_one2one ) Mouse_ Itgav ( ortholog_one2one ) Pig_ ITGAV ( ortholog_one2one ) Rat_ Itgav ( ortholog_one2one ) Rabbit_ ITGAV ( ortholog_one2one ) |
| Ohnologs | ITGA2B, ITGA8, ITGA5 |
| Paralogs | ITGA10, ITGA4, ITGAX, ITGAE, ITGA2, ITGAD, ITGA5, ITGA6, ITGA7, ITGA8, ITGAL, ITGA3, ITGA2B, ITGA11, ITGA1, ITGAM, ITGA9 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003343(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1JV2 (X-ray 3.10A ) 1L5G (X-ray 3.20A ) 1M1X (X-ray 3.30A ) 1U8C (X-ray 3.10A ) 3IJE (X-ray 2.90A ) 4G1E (X-ray 3.00A ) 4G1M (X-ray 2.90A ) 4MMX (X-ray 3.32A ) 4MMY (X-ray 3.18A ) 4MMZ (X-ray 3.10A ) 4O02 (X-ray 3.60A ) 4UM8 (X-ray 2.85A ) 4UM9 (X-ray 2.50A ) 5FFG (X-ray 2.25A ) 5FFO (X-ray 3.49A ) 5NEM (EM 3.10A ) 5NER (EM 3.10A ) 5NET (EM 3.10A ) 5NEU (EM 3.10A ) 6AVQ (EM 35.00A ) 6AVR (EM 35.00A ) 6AVU (EM 35.00A ) 6DJP (EM 4.80A ) 6MK0 (X-ray 3.00A ) 6MSL (X-ray 3.10A ) 6MSU (X-ray 3.11A ) 6NAJ (X-ray 3.10A ) 6OM1 (X-ray 2.66A ) 6OM2 (X-ray 2.77A ) 6UJA (EM 3.30A ) 6UJB (EM 3.51A ) 6UJC (EM 3.56A ) 7Y1T (EM 3.24A ) |
| DBSNP | rs3738918 rs2230615 rs2230616 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}. |
| Mouse PG classification | NA |
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