| Gene Information | |
|---|---|
| Gene Name | PSMA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 261 |
| Protein Names | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) |
| Target Name | proteasome subunit alpha type-4 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000041357 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P25789 |
| Gene Card | PSMA4 |
| Uniprot ID | P25789 |
| Pfam | PF00227; PF10584 |
| In ASD | no |
| Allosteric Prediction | yes (0.177833246) |
| Ortholog in Animals | Alpaca_ PSMA4 ( ortholog_one2one ) GuineaPig_ PSMA4 ( ortholog_one2one ) Macaque_ PSMA4 ( ortholog_one2one ) Mouse_ Psma4 ( ortholog_one2one ) Pig_ PSMA4 ( ortholog_one2one ) Rat_ Psma4 ( ortholog_one2one ) Rabbit_ PSMA4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PSMB11, PSMA7, PSMA6, PSMA3, PSMB5, PSMB4, PSMB6, PSMA8, PSMA5, PSMA2, PSMB2, PSMB7, PSMB1, PSMA1, PSMB9, PSMB10, PSMB8, PSMB3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.330392(Chimpanzee);0.223315(Mouse);0.565836(Rat);0.244411(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4R3O (X-ray 2.60A ) 4R67 (X-ray 2.89A ) 5A0Q (EM 3.50A ) 5GJQ (EM 4.50A ) 5GJR (EM 3.50A ) 5L4G (EM 4.02A ) 5LE5 (X-ray 1.80A ) 5LEX (X-ray 2.20A ) 5LEY (X-ray 1.90A ) 5LEZ (X-ray 2.19A ) 5LF0 (X-ray 2.41A ) 5LF1 (X-ray 2.00A ) 5LF3 (X-ray 2.10A ) 5LF4 (X-ray 1.99A ) 5LF6 (X-ray 2.07A ) 5LF7 (X-ray 2.00A ) 5LN3 (EM 6.80A ) 5M32 (EM 3.80A ) 5T0C (EM 3.80A ) 5T0G (EM 4.40A ) 5T0H (EM 6.80A ) 5T0I (EM 8.00A ) 5T0J (EM 8.00A ) 5VFO (EM 3.50A ) 5VFP (EM 4.20A ) 5VFQ (EM 4.20A ) 5VFR (EM 4.90A ) 5VFS (EM 3.60A ) 5VFT (EM 7.00A ) 5VFU (EM 5.80A ) 6AVO (EM 3.80A ) 6E5B (X-ray 2.77A ) 6KWY (EM 2.72A ) 6MSB (EM 3.00A ) 6MSD (EM 3.20A ) 6MSE (EM 3.30A ) 6MSG (EM 3.50A ) 6MSH (EM 3.60A ) 6MSJ (EM 3.30A ) 6MSK (EM 3.20A ) 6R70 (EM 3.50A ) 6REY (EM 3.00A ) 6RGQ (EM 2.60A ) 6WJD (EM 4.80A ) 6WJN (EM 5.70A ) 6XMJ (EM 3.00A ) 7AWE (X-ray 2.29A ) 7B12 (X-ray 2.43A ) 7LXV (EM 3.40A ) 7NHT (EM 2.80A ) 7PG9 (EM 3.70A ) 7V5G (EM 4.47A ) 7V5M (EM 3.88A ) 7W37 (EM 3.00A ) 7W38 (EM 3.10A ) 7W39 (EM 3.20A ) 7W3A (EM 3.50A ) 7W3B (EM 3.60A ) 7W3C (EM 3.40A ) 7W3F (EM 3.30A ) 7W3G (EM 3.20A ) 7W3H (EM 3.20A ) 7W3I (EM 3.50A ) 7W3J (EM 3.50A ) 7W3K (EM 3.60A ) 7W3M (EM 3.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:Q9R1P0, ECO:0000269|PubMed:34711951}. |
| Mouse PG classification | NA |
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