| Gene Information | |
|---|---|
| Gene Name | PTPN18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 460 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000072135 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99952 |
| Gene Card | PTPN18 |
| Uniprot ID | Q99952 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | no (-0.548899942) |
| Ortholog in Animals | Alpaca_ PTPN18 ( ortholog_one2one ) GuineaPig_ PTPN18 ( ortholog_one2one ) Macaque_ PTPN18 ( ortholog_one2one ) Mouse_ Ptpn18 ( ortholog_one2one ) Pig_ PTPN18 ( ortholog_one2one ) Rat_ Ptpn18 ( ortholog_one2one ) Rabbit_ PTPN18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, colon and several tumor-derived cell lines. {ECO:0000269|PubMed:8950995}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OC3 (X-ray 1.50A ) 4GFU (X-ray 2.00A ) 4GFV (X-ray 2.10A ) 4NND (X-ray 2.50A ) |
| DBSNP | rs3739124 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |