| Gene Information | |
|---|---|
| Gene Name | INPPL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1258 |
| Protein Names | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) (Protein 51C) (SH2 domain-containing inositol 5'-phosphatase 2) (SH2 domain-containing inositol phosphatase 2) (SHIP-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000165458 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15357 |
| Gene Card | INPPL1 |
| Uniprot ID | O15357 |
| Pfam | PF03372; PF00536; PF00017 |
| In ASD | yes |
| Allosteric Prediction | yes (0.478438394) |
| Ortholog in Animals | Alpaca_ INPPL1 ( ortholog_one2one ) Dog_ INPPL1 ( ortholog_one2one ) GuineaPig_ INPPL1 ( ortholog_one2one ) Macaque_ INPPL1 ( ortholog_one2one ) Mouse_ Inppl1 ( ortholog_one2one ) Pig_ INPPL1 ( ortholog_one2one ) Rat_ Inppl1 ( ortholog_one2one ) Rabbit_ INPPL1 ( ortholog_one2one ) |
| Ohnologs | INPP5D |
| Paralogs | SH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, SACM1L, OCRL, INPP5D, INPP5F, INPP5J, SYNJ1, INPP5B, INPP5K |
| Tissue | NA |
| Tissue Specificity | Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets. Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes. {ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:8530088, ECO:0000269|PubMed:9367831, ECO:0000269|PubMed:9660833}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K4P (NMR - ) 2KSO (NMR - ) 2MK2 (NMR - ) 3NR8 (X-ray 2.80A ) 4A9C (X-ray 2.10A ) 5OKM (X-ray 1.96A ) 5OKN (X-ray 2.65A ) 5OKO (X-ray 1.94A ) 5OKP (X-ray 1.85A ) 6SQU (X-ray 2.27A ) 6SRR (X-ray 2.45A ) |
| DBSNP | rs397514511 rs61749195 rs397514510 rs116848359 rs397514512 rs70940821 rs11548491 rs1049472 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:11349134}. Cytoplasm, cytoskeleton. Membrane {ECO:0000269|PubMed:11739414}; Peripheral membrane protein. Cell projection, filopodium {ECO:0000269|PubMed:12676785}. Cell projection, lamellipodium {ECO:0000269|PubMed:12676785}. Basal cell membrane {ECO:0000250|UniProtKB:F1PNY0}. Nucleus {ECO:0000250|UniProtKB:D7PF45}. Nucleus speckle {ECO:0000250|UniProtKB:D7PF45}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:F1PNY0}. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type (PubMed:11739414). Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring. {ECO:0000269|PubMed:11739414}. |
| Mouse PG classification | NA |
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