| Gene Information | |
|---|---|
| Gene Name | PTPN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 415 |
| Protein Names | Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP) |
| Target Name | tyrosine-protein phosphatase non-receptor type 2 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000175354 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17706 |
| Gene Card | PTPN2 |
| Uniprot ID | P17706 |
| Pfam | PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (1.0001308) |
| Ortholog in Animals | Alpaca_ PTPN2 ( ortholog_one2one ) Dog_ PTPN2 ( ortholog_one2one ) GuineaPig_ PTPN2 ( ortholog_one2one ) Macaque_ PTPN2 ( ortholog_one2one ) Mouse_ Ptpn2 ( ortholog_one2one ) Pig_ PTPN2 ( ortholog_one2one ) Rat_ Ptpn2 ( ortholog_one2one ) Rabbit_ PTPN2 ( ortholog_one2one ) |
| Ohnologs | PTPN1 |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta. {ECO:0000269|PubMed:1731319, ECO:0000269|PubMed:2546150}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.021238(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1L8K (X-ray 2.56A ) 6ZZ4 (X-ray 2.43A ) 7F5N (X-ray 1.93A ) 7F5O (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}.; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:9488479}. |
| Mouse PG classification | NA |
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