| Gene Information | |
|---|---|
| Gene Name | SETMAR |
| Organism | Homo sapiens (Human) |
| Gene Length | 684 |
| Protein Names | Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 55 ( ENSG00000170364 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q53H47 |
| Gene Card | SETMAR |
| Uniprot ID | Q53H47 |
| Pfam | PF17906; PF05033; PF00856; PF01359 |
| In ASD | no |
| Allosteric Prediction | no (-0.492515267) |
| Ortholog in Animals | Alpaca_ SETMAR ( ortholog_one2one ) Macaque_ SETMAR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GVQW3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269|PubMed:16332963}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BO5 (X-ray 1.59A ) 3F2K (X-ray 1.85A ) 3K9J (X-ray 1.90A ) 3K9K (X-ray 2.55A ) 7S03 (X-ray 2.37A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:18263876}. Chromosome {ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22231448}. Note=Recruited on damaged DNA at sites of double-strand breaks. {ECO:0000269|PubMed:18263876}. |
| Mouse PG classification | NA |
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