| Gene Information | |
|---|---|
| Gene Name | OSMR |
| Organism | Homo sapiens (Human) |
| Gene Length | 979 |
| Protein Names | Oncostatin-M-specific receptor subunit beta (Interleukin-31 receptor subunit beta) (IL-31 receptor subunit beta) (IL-31R subunit beta) (IL-31R-beta) (IL-31RB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000145623 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99650 |
| Gene Card | OSMR |
| Uniprot ID | Q99650 |
| Pfam | PF00041; PF17971 |
| In ASD | no |
| Allosteric Prediction | no (-0.033358734) |
| Ortholog in Animals | Alpaca_ OSMR ( ortholog_one2one ) Dog_ OSMR ( ortholog_one2one ) GuineaPig_ OSMR ( ortholog_one2one ) Macaque_ OSMR ( ortholog_one2one ) Mouse_ Osmr ( ortholog_one2one ) Pig_ OSMR ( ortholog_one2one ) Rat_ Osmr ( ortholog_one2one ) Rabbit_ OSMR ( ortholog_one2one ) |
| Ohnologs | IL12RB2 |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | NA |
| Tissue Specificity | Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038). {ECO:0000269|PubMed:21261663, ECO:0000269|PubMed:8999038}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34675408 rs17855841 rs10941412 rs2278329 rs63750560 rs387906821 rs63750567 rs387906822 rs387906823 rs3749737 rs34080825 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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