| Gene Information | |
|---|---|
| Gene Name | IRF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Interferon regulatory factor 6 (IRF-6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000117595 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14896 |
| Gene Card | IRF6 |
| Uniprot ID | O14896 |
| Pfam | PF00605; PF10401 |
| In ASD | no |
| Allosteric Prediction | no (-0.73485469) |
| Ortholog in Animals | Alpaca_ IRF6 ( ortholog_one2one ) Dog_ IRF6 ( ortholog_one2one ) GuineaPig_ IRF6 ( ortholog_one2one ) Macaque_ IRF6 ( ortholog_one2one ) Mouse_ Irf6 ( ortholog_one2one ) Pig_ IRF6 ( ortholog_one2one ) Rat_ Irf6 ( ortholog_one2one ) Rabbit_ IRF6 ( ortholog_one2one ) |
| Ohnologs | IRF5, IRF9 |
| Paralogs | IRF4, IRF7, IRF5, IRF3, IRF9, IRF2, IRF8, IRF1 |
| Tissue | NA |
| Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. {ECO:0000269|PubMed:16049006}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28942093 rs28942094 rs2077940645 rs387906967 rs121434229 rs776236749 rs886039388 rs121434226 rs121434227 rs121434227 rs1571983348 rs1553247774 rs2235371 rs779827384 rs121434231 rs1185412313 rs121434230 rs28942095 rs387906968 rs886038202 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |