| Gene Information | |
|---|---|
| Gene Name | PARK7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 189 |
| Protein Names | Parkinson disease protein 7 (Maillard deglycase) (Oncogene DJ1) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) |
| Target Name | protein dj-1 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000116288 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q99497 |
| Gene Card | PARK7 |
| Uniprot ID | Q99497 |
| Pfam | PF01965 |
| In ASD | yes |
| Allosteric Prediction | yes (1.235869665) |
| Ortholog in Animals | Alpaca_ PARK7 ( ortholog_one2one ) Dog_ PARK7 ( ortholog_one2one ) GuineaPig_ PARK7 ( ortholog_one2one ) Mouse_ Park7 ( ortholog_one2one ) Pig_ PARK7 ( ortholog_one2one ) Rat_ Park7 ( ortholog_one2many ) Rabbit_ PARK7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart. Detected at slightly lower levels in placenta and brain (at protein level). Detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Expressed by pancreatic islets at higher levels than surrounding exocrine tissues (PubMed:22611253). {ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:14662519, ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:22611253, ECO:0000269|PubMed:9070310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1J42 (X-ray 2.50A ) 1P5F (X-ray 1.10A ) 1PDV (X-ray 1.80A ) 1PDW (X-ray 2.20A ) 1PE0 (X-ray 1.70A ) 1Q2U (X-ray 1.60A ) 1SOA (X-ray 1.20A ) 1UCF (X-ray 1.95A ) 2OR3 (X-ray 1.20A ) 2R1T (X-ray 1.70A ) 2R1U (X-ray 1.50A ) 2R1V (X-ray 1.70A ) 2RK3 (X-ray 1.05A ) 2RK4 (X-ray 1.15A ) 2RK6 (X-ray 1.15A ) 3B36 (X-ray 1.50A ) 3B38 (X-ray 1.85A ) 3B3A (X-ray 1.50A ) 3BWE (X-ray 2.40A ) 3CY6 (X-ray 1.35A ) 3CYF (X-ray 1.60A ) 3CZ9 (X-ray 1.15A ) 3CZA (X-ray 1.20A ) 3EZG (X-ray 1.15A ) 3F71 (X-ray 1.20A ) 3SF8 (X-ray 1.56A ) 4BTE (X-ray 1.38A ) 4MNT (X-ray 1.58A ) 4MTC (X-ray 1.47A ) 4N0M (X-ray 1.95A ) 4N12 (X-ray 1.48A ) 4OGF (X-ray 1.60A ) 4OQ4 (X-ray 1.49A ) 4P2G (X-ray 1.35A ) 4P34 (X-ray 1.55A ) 4P35 (X-ray 1.75A ) 4P36 (X-ray 1.18A ) 4RKW (X-ray 1.50A ) 4RKY (X-ray 1.50A ) 4S0Z (X-ray 1.45A ) 4ZGG (X-ray 1.23A ) 5IP5 (X-ray 1.66A ) 5SY6 (X-ray 1.15A ) 5SY9 (X-ray 1.10A ) 5SYA (X-ray 1.10A ) 6AF5 (X-ray 1.65A ) 6AF7 (X-ray 1.30A ) 6AF9 (X-ray 1.39A ) 6AFA (X-ray 1.65A ) 6AFB (X-ray 1.60A ) 6AFC (X-ray 1.45A ) 6AFD (X-ray 1.48A ) 6AFE (X-ray 1.50A ) 6AFF (X-ray 1.60A ) 6AFG (X-ray 1.50A ) 6AFH (X-ray 1.65A ) 6AFI (X-ray 1.65A ) 6AFJ (X-ray 1.48A ) 6AFL (X-ray 1.60A ) 6E5Z (X-ray 1.35A ) 6M8Z (X-ray 1.83A ) 7C62 (X-ray 2.03A ) 7PA2 (X-ray 1.21A ) 7PA3 (X-ray 1.42A ) |
| DBSNP | rs74315351 rs137853051 rs74315353 rs71653619 rs774005786 rs74315352 rs368420490 rs74315354 rs28938172 rs777026628 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q99LX0}; Lipid-anchor {ECO:0000250|UniProtKB:Q99LX0}. Cytoplasm {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:28596309}. Nucleus {ECO:0000269|PubMed:12851414, ECO:0000269|PubMed:14579415, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:16390825, ECO:0000269|PubMed:28596309}. Membrane raft {ECO:0000250|UniProtKB:O88767}. Mitochondrion {ECO:0000269|PubMed:15181200, ECO:0000269|PubMed:18711745, ECO:0000269|PubMed:19229105, ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion. Translocates to the mitochondrion and subsequently to the nucleus in response to oxidative stress and exerts an increased cytoprotective effect against oxidative damage (PubMed:18711745). Detected in tau inclusions in brains from neurodegenerative disease patients (PubMed:14705119). Membrane raft localization in astrocytes and neuronal cells requires palmitoylation. {ECO:0000269|PubMed:14705119, ECO:0000269|PubMed:18711745}. |
| Mouse PG classification | NA |
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