| Gene Information | |
|---|---|
| Gene Name | CEACAM8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 349 |
| Protein Names | Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000124469 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P31997 |
| Gene Card | CEACAM8 |
| Uniprot ID | P31997 |
| Pfam | PF13895; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.083570053) |
| Ortholog in Animals | Alpaca_ CEACAM8 ( ortholog_one2one ) Dog_ CEACAM1 ( ortholog_many2many ) Macaque_ CEACAM8 ( ortholog_one2one ) Mouse_ Ceacam10 ( ortholog_many2many ) Mouse_ Ceacam1 ( ortholog_many2many ) Mouse_ Ceacam2 ( ortholog_many2many ) Rat_ Ceacam1 ( ortholog_many2many ) Rat_ Ceacam4 ( ortholog_many2many ) Rat_ Ceacam6 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CEACAM19, HEPACAM2, HEPACAM, VSTM5, CEACAM7, CEACAM6, CEACAM1, CEACAM5, CEACAM3, PSG1, PSG8, PSG9, PSG3, PSG7, PSG11, PSG2, PSG4, PSG5, PSG6, CEACAM4, CEACAM21, CEACAM16, CEACAM20, CEACAM18 |
| Tissue | bone.marrow |
| Tissue Specificity | Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DKS (NMR - ) 4WTZ (X-ray 2.52A ) 4Y88 (X-ray 1.45A ) 4YIQ (X-ray 1.85A ) |
| DBSNP | rs28367882 rs35221575 rs1041997 rs1126458 rs8103051 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:2208113}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2208113}. Cell surface {ECO:0000269|PubMed:8776764}. |
| Mouse PG classification | NA |
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